A wireframe may be passed to a graphic design artist who will try to replicate the desired layout. The design artist may start to develop low fidelity prototypes that can be compared to the wireframe design.
These prototypes are created using pen and paper. They should be shown to the end-user group and their feedback should be considered when the final version of the site is being developed.
Low fidelity prototypes will often include more detail than a wireframe:
text areas might contain all intended text
image and video areas might contain hand-drawn versions of the final image/video still