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For decades, people suffering from chronic depression have relied on medicines that affect the levels of chemicals in the brain like serotonin, which regulate mood and emotion. But ten percent of people don鈥檛 benefit from any of the existing treatments for this devastating condition.

Sisters Annie and Kathryn have both been diagnosed with long-term depression that makes it hard for them to experience pleasure as others do. But they鈥檙e interested in whether there are new solutions on the horizon that could improve their wellbeing, in particular ones that don鈥檛 necessarily involve conventional medication.

Datshiane Navanayagam learns how a technique called mindfulness could strengthen neural connections in bits of the brain that communicate with each other. This, it鈥檚 said, may harness the ability of the brain to adapt and self-repair which can change people鈥檚 emotional responses to life鈥檚 ups and downs. She meets a psychologist who shows how this simple technique could improve our overall ability to process information and reverse negative thought patterns.

CrowdScience also hears about cutting edge research into the use of psychedelics as potential treatment for depression and heads to the UK鈥檚 only centre for ketamine therapy, where patients say a drug once popular with partygoers, is having a profound effect on their mental health.

Produced by Marijke Peters for 91热爆 World Service.

(Photo: A woman sitting on the top of a mountain and meditating. Credit: Getty Images)