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The weekend night shifts begin with 45 ambulance crews standing ready to help the people of Merseyside. A car has overturned at a roundabout, and the driver has fled the scene. Before long he returns and becomes their patient.

Before long all the ambulances have been called out. Senior paramedic Tony is working alone when he鈥檚 called to a patient who is believed to have had a fit. Tony decides the patient must go to hospital, but with no ambulances available, he and the patient are forced to begin a 40-minute wait in the cold.

Tony is dispatched again when a caller reports that a man is slumped in his car in the city centre. While en route, the driver comes round and turns on the good samaritan who made the call to get him help. When Tony arrives he finds the caller is now the patient and is in the back of the ambulance needing emergency treatment following the attack. As he is being driven to the nearest major trauma centre, things take a further turn for the worse.