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This third episode joins the team as they are being kept busy dealing with with a repeat caller who moves around Manchester's canals on his barge.

Scott and Ana are the first to track him down, and they remain patient in the face of his frustrating behavior, taking time with him in a bid to find out what lies behind his frequent calls. They are then plunged sent to deal with a woman who has found an unusual bite mark on her ankle after returning from a holiday in Thailand.

When a member of the public phones in to report that a man is threatening suicide, ambulance crew Pragna and Amy are dispatched and arrive to find Scott and Ana's patient from earlier in the day.

In south east Manchester, paramedics Sarah and Alan are called to a deal with a baby who has pulled a cup of hot tea off the kitchen surface. They need to get him to hospital urgently to help prevent the burns which will leave permanent scars.

The normal routine of the night shift is suddenly disrupted when multiple 999 calls come in reporting a serious incident near the Trafford Centre. Thoughts quickly turn to the Manchester Arena attacks and the constant fear of a repeat terror incident. However, as more information is relayed from the scene, it becomes clear that it is no terrorism but an extremely serious road traffic incident. Twelve vehicles are dispatched to the incident which has direct repercussions on how quickly other calls that flow in through the night can be dealt with.

Paramedics Amy and Pragna are sent to a man who has been lying immobilised in his garden with a seized back for three hours - and have to apologise for the delays getting a crew out to him. On their final job of the night, they deal with a 68-year-old woman who they fear may have suffered a stroke.