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EastEnders actor Shane Richie makes an appeal to raise funds for the Huntington's Disease Association, a charity for which Shane is patron. Shane became involved in 2004, when EastEnders featured a character who was suffering from the incurable and degenerative illness. A viewer suffering from the disease wrote to Shane personally, and he has since met her and they have become family friends. Shane now works to do all he can to help people affected by this hereditary neurological disorder, which slowly causes dementia and difficulties with speaking, swallowing and walking.

The film features Richard, who is in the middle stages of the disease; and Matt, who lost his father to the disease and knows that he too carries the gene. Matt talks about how, with the help of the Huntington's Disease Association, he is coming to terms with the fact he will also start showing symptoms at some point in the future.