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Newport County 2-3 Leyton Orient
Leyton Orient's perfect start continued despite Newport clawing their way back after conceding two early goals.
Paul McCallum headed the opener from Dean Cox's left-flank cross and Jay Simpson added a second with a left-foot curler with just seven minutes played.
McCallum's header then hit the bar before Scott Bowden finished a fine move to pull one back near half time.
Mark Byrne's dipping shot from distance a minute later brought County level but Cox struck to claim a fourth O's win.
Newport substitute Josh Laurent wasted a great chance from 12 yards to grab a stoppage-time equaliser.
Newport manager Terry Butcher told 91热爆 Radio Wales:
"I felt we deserved much more from the game. We've had chances to equalise towards the end of the game.
"They scored their third goal totally against the run of play - we came out in the second half and totally dominated it.
"We are bitterly disappointed again that we've allowed all that good possession and good chances to slip by. But the win will come."
Leyton Orient boss Ian Hendon speaks to 91热爆 London 94.9:
"We set off really well and started superbly, Paul McCallum should have made it three. Had that gone in I think that would have killed the game there and then with the free header that he missed.
"It was a tough, tough game second half but Coxy's popped up with another one to make it 3-2 and we had to hang on in the end
"At half time I said it's up to you now - you can go out there and fade and die or you can stand up and try and dig out a winner."